Game & Wario is a WarioWare-like Wii U game, which will be played only with the GamePad. I think it looks interesting...I also think that they should call the game "WarioWare," since that's more or less what it is. Game & Wario's not the final title, though, so that could change.
Saw it on the press site moments after the presentation. This looks like it'll be interesting, I wonder if it's suppose to be a new take on the series. It mentions that Wario and his Diamond City friends are back and there is a screenshot with Wario wanting to make games, so I'll assume it's a new entry and not a sub series.
Game & Wario is kind of an interesting name since it's like a reference to Game & Watch.